An Analysis of Trends of Incidence And Pathological Study of Non Specific Granulomatous Prostatitis Encountered in Turp Specimens And Its Correlation with Serum PSA Levels

ntroduction: Granulomatousprostatitis is an inflammatory condition of the prostate that histologically features the presence of granulomas. In general, granulomatousprostatitis accounts for fewer than 1% of benign inflammatory conditions of the prostate. The epidemiologic correlations depend in part on the etiology. Methods: The study was done on 94 specimens over a period of three years. Sections from each case of histopathologically diagnosed non specific granulomatousprostatitis on hematoxylin and eosin (H & E) were stained with Periodic Acid Schiff (PAS) and Ziehlneelsen stain (Z N stain) for acid fast bacilli to confirm infectious granulomatousprostatitis. Results: Out of total 94 cases, 11 cases(11.70%) of NSGP, 8 cases (8.51%) of prostatic adenocarcinoma,1 case (1.07% of prostatic abscess,1case (1.07%) of prostatic TB and 63 cases (67.01%) of BPH and 10 cases (10.64%) of BPH with chronic prostatitis were observed. All the cases(11.70%) of non specific granulomatousprostatitis shows raised PSA level and clinically they were diagnosed as carcinoma prostate in 9 cases and 2 cases as benign prostatic hyperplasia with marginally elevated PSA level. None of these were suspected as granulomatousprostatitis on clinical basis. Conclusion: Distinction between non specific and infectious granulomatousprostatitis is important for therapeutic reasons to reduce the unnecessary hospital treatment and financial burden on patients as these lesions closely mimic prostatic carcinoma. Moreover there is no specific pattern of clinical,biochemical and ultrasound findings that allows the diagnosis of granulomatousprostatitis or differentiates it from prostatic carcinoma.Hence,histomorphological diagnosis is gold standard in differentiating various prostatic lesions.